ABSTRACT
Population aging increases the demand for human aging research and its clinical applications.Traditionally, the chronological age(CA), that is, the age based on the calendar, is used to describe the state of aging.However, the aging process and speed among individuals are not consistent and often show clear individual differences in biological aging.Therefore, CA cannot truly reflect people's conditions of body structure and function, has drawbacks leading to unreliable and wrong assessment, and is unable to accurately describe the human body's state of aging.In recent years, it has been proposed that the biological age(BA)should be used to more comprehensively and accurately describe the stage of human aging.Combining mathematical algorithms with a variety of biomarkers, predictive models can be constructed to quantify BA.These approaches have been increasingly appreciated for their improved accuracy and received further investigation.This article reviews the value of BA, currently commonly used calculation methods and their progress and prospects in healthy aging.